› 3ib2

X-ray diffraction
2.29Å resolution

structure of the complex of C-terminal half (C-lobe) of bovine lactoferrin with alpha-methyl-4-(2-methylpropyl) benzene acetic acid

Released:
DOI: 10.2210/pdb3ib2/pdb
PDB 3ib2 coloured by chain and viewed from the front.
PDB 3ib2 coloured by chain and viewed from the side.
PDB 3ib2 coloured by chain and viewed from the top.
Source organism: Bos taurus
Primary publication:
The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin.
Mir R, Singh N, Vikram G, Kumar RP, Sinha M, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP
Biophys J 97 3178-86 (2009)
PMID: 20006955

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Lactotransferrin Chain: A
Molecule details ›
Chain: A
Length: 345 amino acids
Theoretical weight: 37.66 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P24627 (Residues: 361-705; Coverage: 50%)
Gene name: LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand IBP 1 x IBP
Ligand FE 1 x FE
Ligand CO3 1 x CO3
Ligand ZN 2 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 63.319Å b: 50.48Å c: 66.116Å
α: 90° β: 107.75° γ: 90°
R-values:
R R work R free
0.168 0.165 0.22

Quick links

Citations

5 review citations

The Halogen Bond.
Cavallo et al. (2016)
4 more

1 mention without citation

Detect, correct, retract: How to manage incorrect structural models.
Wlodawer et al. (2018)