X-ray diffraction
3Å resolution

Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose


Function and Biology Details

Reactions catalysed:
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.58 KDa
Source organism: Aplysia californica
Expression system: Komagataella pastoris
  • Canonical: P29241 (Residues: 25-282; Coverage: 100%)
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P61
Unit cell:
a: 56.726Å b: 56.726Å c: 360.333Å
α: 90° β: 90° γ: 120°
R R work R free
0.223 0.221 0.268
Expression system: Komagataella pastoris