X-ray diffraction
1.83Å resolution

Crystal structure of ADP ribosyl cyclase complexed with substrate NAD


Function and Biology Details

Reactions catalysed:
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.51 KDa
Source organism: Aplysia californica
Expression system: Komagataella pastoris
  • Canonical: P29241 (Residues: 25-282; Coverage: 100%)
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 69.501Å b: 58.317Å c: 71.515Å
α: 90° β: 101.2° γ: 90°
R R work R free
0.178 0.175 0.231
Expression system: Komagataella pastoris