PDBe 3hiz

X-ray diffraction
3.3Å resolution

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 373 amino acids
Theoretical weight: 44.26 KDa
Source organism: Homo sapiens
Expression system: Heliothis
  • Canonical: P27986 (Residues: 322-694; Coverage: 52%)
  • Best match: P27986-5 (Residues: 1-331)
Gene names: GRB1, PIK3R1
Sequence domains:
Structure domains: SH2 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 115.316Å b: 120.697Å c: 153.963Å
α: 90° β: 90° γ: 90°
R R work R free
0.263 0.26 0.333
Expression system: Heliothis