3h52

X-ray diffraction
2.8Å resolution

Crystal structure of the antagonist form of human glucocorticoid receptor

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glucocorticoid receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 254 amino acids
Theoretical weight: 29.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04150 (Residues: 528-777; Coverage: 32%)
Gene names: GRL, NR3C1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor corepressor 1 Chains: M, N
Molecule details ›
Chains: M, N
Length: 19 amino acids
Theoretical weight: 2.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75376 (Residues: 2258-2276; Coverage: 1%)
Gene names: KIAA1047, NCOR1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 99.53Å b: 99.53Å c: 252.43Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.226 0.283
Expression systems:
  • Escherichia coli
  • Not provided