3gm3

X-ray diffraction
2.6Å resolution

Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.
Biochem. Biophys. Res. Commun. 383 347-52 (2009)
PMID: 19358827

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 2-beta Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 16.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14289 (Residues: 861-1009; Coverage: 15%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Sequence domains: Focal adhesion targeting region
Structure domains: Nucleotidyltransferases domain 2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Unit cell:
a: 28.462Å b: 42.791Å c: 129.502Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.255 0.289
Expression system: Escherichia coli