3gh3

X-ray diffraction
1.8Å resolution

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.

Released:

Function and Biology Details

Reaction catalysed:
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2'-phospho-ADP-ribosyl cyclase Chains: A, B
Molecule details ›
Chains: A, B
Length: 247 amino acids
Theoretical weight: 28.3 KDa
Source organism: Bos taurus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9TTF5 (Residues: 32-278; Coverage: 98%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 47.483Å b: 80.879Å c: 151.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.223
Expression system: Komagataella pastoris