X-ray diffraction
1.45Å resolution

Crystal structure of the C-terminal domain of human MDA5

Source organism: Homo sapiens
Entry author: Li P

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Interferon-induced helicase C domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9BYX4 (Residues: 893-1017; Coverage: 12%)
Gene names: IFIH1, MDA5, RH116
Structure domains: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 28.41Å b: 60.92Å c: 36.443Å
α: 90° β: 102.58° γ: 90°
R R work R free
0.18 0.18 0.204
Expression system: Escherichia coli