PDBe 3g9v

X-ray diffraction
2.76Å resolution

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-22 receptor subunit alpha-2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 211 amino acids
Theoretical weight: 24.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q969J5 (Residues: 21-263; Coverage: 87%)
  • Best match: Q969J5-2 (Residues: 21-231)
Gene names: IL22RA2, UNQ5793/PRO19598/PRO19822
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins
Interleukin-22 Chains: B, D
Molecule details ›
Chains: B, D
Length: 151 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZX6 (Residues: 29-179; Coverage: 100%)
Gene names: IL22, ILTIF, UNQ3099/PRO10096, ZCYTO18
Sequence domains: Interleukin 22 IL-10-related T-cell-derived-inducible factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P41
Unit cell:
a: 67.948Å b: 67.948Å c: 172.533Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.282
Expression system: Escherichia coli