PDBe 3g7v

X-ray diffraction
1.86Å resolution

Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Islet amyloid polypeptide; Maltose/maltodextrin-binding periplasmic protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 408 amino acids
Theoretical weight: 44.44 KDa
Source organisms: Expression system: Escherichia coli
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene names: IAPP, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 104.025Å b: 96.407Å c: 103.996Å
α: 90° β: 90.53° γ: 90°
R R work R free
0.178 0.176 0.205
Expression system: Escherichia coli