PDBe 3g43

X-ray diffraction
2.1Å resolution

Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP24 (Residues: 2-149; Coverage: 99%)
Gene names: CALM2, CAM2, CAMB
Sequence domains: EF-hand domain pair
Voltage-dependent L-type calcium channel subunit alpha-1C Chains: E, F
Molecule details ›
Chains: E, F
Length: 81 amino acids
Theoretical weight: 9.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13936 (Residues: 1609-1682; Coverage: 3%)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID, CAMD BEAMLINE GCPCC
Spacegroup: P212121
Unit cell:
a: 39.79Å b: 113.98Å c: 182.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.22 0.269
Expression system: Escherichia coli