X-ray diffraction
2.2Å resolution

Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hepatocyte nuclear factor 4-alpha Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 25.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P41235 (Residues: 148-377; Coverage: 49%)
Gene names: HNF4, HNF4A, NR2A1, TCF14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
PPARgamma Coactivator-1a (PGC-1a) Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 784 Da
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P4222
Unit cell:
a: 113.049Å b: 113.049Å c: 57.322Å
α: 90° β: 90° γ: 90°
R R work R free
0.195 0.19 0.236
Expression system: Escherichia coli