3frp

X-ray diffraction
2.61Å resolution

Crystal Structure of Cobra Venom Factor, a Co-factor for C3- and C5 convertase CVFBb

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cobra venom factor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 627 amino acids
Theoretical weight: 69.58 KDa
Source organism: Naja kaouthia
UniProt:
  • Canonical: Q91132 (Residues: 23-649; Coverage: 39%)
Sequence domains:
Structure domains:
Cobra venom factor gamma chain Chain: G
Molecule details ›
Chain: G
Length: 252 amino acids
Theoretical weight: 28.42 KDa
Source organism: Naja kaouthia
UniProt:
  • Canonical: Q91132 (Residues: 733-984; Coverage: 16%)
Sequence domains: Alpha-2-macroglobulin family
Structure domains:
Cobra venom factor beta chain Chain: B
Molecule details ›
Chain: B
Length: 379 amino acids
Theoretical weight: 43.63 KDa
Source organism: Naja kaouthia
UniProt:
  • Canonical: Q91132 (Residues: 1264-1642; Coverage: 23%)
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 134.138Å b: 151.141Å c: 76.787Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.248 0.297