X-ray diffraction
2.15Å resolution

Catalytic complex of Human Glucokinase

Source organism: Homo sapiens
Primary publication:
The active conformation of human glucokinase is not altered by allosteric activators.
Acta Crystallogr. D Biol. Crystallogr. 67 929-35 (2011)
PMID: 22101819

Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hexokinase-4 Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P35557 (Residues: 12-465; Coverage: 98%)
Gene name: GCK
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 65.88Å b: 82.12Å c: 86.83Å
α: 90° β: 90° γ: 90°
R R work R free
0.2 0.197 0.255
Expression system: Escherichia coli