3fe2

X-ray diffraction
2.6Å resolution

Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable ATP-dependent RNA helicase DDX5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 242 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17844 (Residues: 68-307; Coverage: 39%)
Gene names: DDX5, G17P1, HELR, HLR1
Sequence domains: DEAD/DEAH box helicase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: C2221
Unit cell:
a: 84.57Å b: 106.87Å c: 117.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.273
Expression system: Escherichia coli