X-ray diffraction
1.5Å resolution

Crystal structure of human esterase D

Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
S-formylglutathione + H(2)O = glutathione + formate
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
S-formylglutathione hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 282 amino acids
Theoretical weight: 31.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10768 (Residues: 1-282; Coverage: 100%)
Gene name: ESD
Sequence domains: Putative esterase
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 51.542Å b: 70.724Å c: 65.014Å
α: 90° β: 108.84° γ: 90°
R R work R free
0.179 0.176 0.196
Expression system: Escherichia coli