3fb2

X-ray diffraction
2.3Å resolution

Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.

Released:
Source organism: Homo sapiens
Entry authors: Vorobiev SM, Su M, Seetharaman J, Shastry R, Foote EL, Ciccosanti C, Janjua H, Xiao R, Acton TB, Montelione GT, Tong L, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spectrin alpha chain, non-erythrocytic 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 218 amino acids
Theoretical weight: 25.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13813 (Residues: 1337-1544; Coverage: 8%)
Gene names: NEAS, SPTA2, SPTAN1
Sequence domains: Spectrin repeat
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 65.61Å b: 96.376Å c: 111.145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.248
Expression system: Escherichia coli