X-ray diffraction
2.1Å resolution

Crystal structure and anti-tumor activity of LZ-8 from the fungus Ganoderma lucidium

Source organism: Ganoderma lucidum

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Immunomodulatory protein Ling Zhi-8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.52 KDa
Source organism: Ganoderma lucidum
Expression system: Komagataella pastoris
  • Canonical: P14945 (Residues: 1-111; Coverage: 100%)
Sequence domains: Fungal immunomodulatory protein Fve
Structure domains: Fungal immunomodulatory protein Fve

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 33.19Å b: 86.99Å c: 92.13Å
α: 90° β: 90° γ: 90°
R R work R free
0.222 0.221 0.246
Expression system: Komagataella pastoris