› 3exx

X-ray diffraction
1.35Å resolution

Structure of the T6 human insulin derivative with nickel at 1.35 A resolution

Released:
DOI: 10.2210/pdb3exx/pdb
PDB 3exx coloured by chain and viewed from the front.
PDB 3exx coloured by chain and viewed from the side.
PDB 3exx coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structure of the T6 Human Nickel Insulin Derivative at 1.35 A Resolution.
Prugovecki B, Dodson E, Dodson G, Matkovic-Calogovic D
Croatica Chemica Acta 82 433-438 (2009)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS

Ligands and Environments

2 bound ligands:
Ligand NI 2 x NI
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: R3
Unit cell:
a: 81.411Å b: 81.411Å c: 33.752Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.126 0.124 0.171

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