X-ray diffraction
2.2Å resolution

Crystal Structure of a PALB2 / BRCA2 complex

Source organism: Homo sapiens
Primary publication:
Structural basis for recruitment of BRCA2 by PALB2.
EMBO Rep. 10 990-6 (2009)
PMID: 19609323

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Partner and localizer of BRCA2 Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 39.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q86YC2 (Residues: 835-1186; Coverage: 30%)
Gene names: FANCN, PALB2
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Breast cancer type 2 susceptibility protein Chain: X
Molecule details ›
Chain: X
Length: 19 amino acids
Theoretical weight: 2.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P51587 (Residues: 21-39; Coverage: 1%)
Gene names: BRCA2, FACD, FANCD1

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 82.815Å b: 62.026Å c: 77.975Å
α: 90° β: 108.23° γ: 90°
R R work R free
0.2 0.197 0.253
Expression systems:
  • Spodoptera frugiperda
  • Not provided