3eqt

X-ray diffraction
2Å resolution

Crystal structure of human LGP2 C-terminal domain in complex with dsRNA

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Probable ATP-dependent RNA helicase DHX58 Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96C10 (Residues: 541-678; Coverage: 20%)
Gene names: D11LGP2E, DHX58, LGP2
Sequence domains: C-terminal domain of RIG-I
Structure domains: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
5'-R(*GP*CP*GP*CP*GP*CP*GP*C)-3' Chains: C, D
Molecule details ›
Chains: C, D
Length: 8 nucleotides
Theoretical weight: 2.56 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 116.458Å b: 54.191Å c: 67.203Å
α: 90° β: 97.26° γ: 90°
R-values:
R R work R free
0.214 0.213 0.254
Expression systems:
  • Escherichia coli
  • Not provided