X-ray diffraction
1.8Å resolution

Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2) in complex with a 20-residue VASA peptide


Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SPRY domain-containing SOCS box protein 2 Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 23.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q99619 (Residues: 26-219; Coverage: 74%)
Gene names: GRCC9, SPSB2, SSB2
Sequence domains: SPRY domain
ATP-dependent RNA helicase vasa Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.5 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided
  • Canonical: P09052 (Residues: 184-203; Coverage: 3%)
Gene names: CG46283, vas, vasa

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 34.47Å b: 61.963Å c: 118.581Å
α: 90° β: 90° γ: 90°
R R work R free
0.18 0.178 0.216
Expression systems:
  • Escherichia coli
  • Not provided