X-ray diffraction
3.5Å resolution

Crystal structure of Pdcd4-eIF4A


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eukaryotic initiation factor 4A-I Chains: A, D
Molecule details ›
Chains: A, D
Length: 414 amino acids
Theoretical weight: 46.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P60842 (Residues: 1-406; Coverage: 100%)
Gene names: DDX2A, EIF4A, EIF4A1
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Programmed cell death protein 4 Chain: C
Molecule details ›
Chain: C
Length: 358 amino acids
Theoretical weight: 39.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: Q61823 (Residues: 120-469; Coverage: 75%)
Gene names: Ma3, Pdcd4, Tis
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P213
Unit cell:
a: 198.362Å b: 198.362Å c: 198.362Å
α: 90° β: 90° γ: 90°
R R work R free
0.222 0.22 0.269
Expression system: Escherichia coli