X-ray diffraction
2.26Å resolution

Crystal structure of the human progesterone receptor ligand-binding domain bound to levonorgestrel


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P06401 (Residues: 676-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 58.87Å b: 65.31Å c: 70.62Å
α: 90° β: 96.01° γ: 90°
R R work R free
0.231 0.231 0.279
Expression system: Escherichia coli