3d7c

X-ray diffraction
2.06Å resolution

Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis protein 5-like 2

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 13.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92830 (Residues: 729-837; Coverage: 13%)
Gene names: GCN5, GCN5L2, KAT2A
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 45.428Å b: 72.862Å c: 75.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.179 0.257
Expression system: Escherichia coli