PDBe 3cvh

X-ray diffraction
2.9Å resolution

How TCR-like antibody recognizes MHC-bound peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
H-2 class I histocompatibility antigen, K-B alpha chain Chains: A, M
Molecule details ›
Chains: A, M
Length: 274 amino acids
Theoretical weight: 31.65 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01901 (Residues: 22-295; Coverage: 79%)
Gene names: H2-K, H2-K1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, N
Molecule details ›
Chains: B, N
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ovalbumin Chains: C, O
Molecule details ›
Chains: C, O
Length: 8 amino acids
Theoretical weight: 964 Da
Source organism: Gallus gallus
UniProt:
  • Canonical: P01012 (Residues: 258-265; Coverage: 2%)
Gene name: SERPINB14
25-D1.16 heavy chain Chains: H, Q
Molecule details ›
Chains: H, Q
Length: 219 amino acids
Theoretical weight: 23.53 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
25-D1.16 light chain Chains: L, R
Molecule details ›
Chains: L, R
Length: 209 amino acids
Theoretical weight: 23.1 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 80.57Å b: 111.345Å c: 219.087Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.219 0.296