3c6l

X-ray diffraction
3.4Å resolution

Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR 2W20

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
TCR 2W20 alpha chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 185 amino acids
Theoretical weight: 20.96 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins
TCR 2W20 beta chain Chains: B, F
Molecule details ›
Chains: B, F
Length: 236 amino acids
Theoretical weight: 26.49 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins
H-2 class II histocompatibility antigen, A-B alpha chain Chains: C, G
Molecule details ›
Chains: C, G
Length: 182 amino acids
Theoretical weight: 20.6 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P14434 (Residues: 27-208; Coverage: 78%)
Gene name: H2-Aa
Sequence domains:
Structure domains:
H-2 class II histocompatibility antigen, A beta chain Chains: D, H
Molecule details ›
Chains: D, H
Length: 217 amino acids
Theoretical weight: 24.94 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P14483 (Residues: 21-218; Coverage: 77%)
Gene names: H2-Ab1, H2-iabeta
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 46.54Å b: 113.93Å c: 386.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.268 0.268 0.325
Expression system: Spodoptera frugiperda