3bu8

X-ray diffraction
2.15Å resolution

Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero octamer
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Telomeric repeat-binding factor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 26.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15554 (Residues: 84-318; Coverage: 43%)
Gene names: TERF2, TRBF2, TRF2
Sequence domains: Telomere repeat binding factor (TRF)
Structure domains: Telomere repeat-binding factor, dimerisation domain
TERF1-interacting nuclear factor 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 19 amino acids
Theoretical weight: 2.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BSI4 (Residues: 258-275; Coverage: 4%)
Gene names: TIN2, TINF2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P41212
Unit cell:
a: 75.235Å b: 75.235Å c: 181.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.256
Expression system: Escherichia coli BL21(DE3)