Function and Biology Details
Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assemblies composition:
Assembly name:
PDBe Complex ID:
PDB-CPX-127198 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibitor of nuclear factor kappa-B kinase subunit beta
Molecule details ›
Chains: A, C
Length: 48 amino acids
Theoretical weight: 5.44 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: I-kappa-kinase-beta NEMO binding domain
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Length: 48 amino acids
Theoretical weight: 5.44 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
O14920 (Residues: 701-745; Coverage: 6%)
Sequence domains: I-kappa-kinase-beta NEMO binding domain
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
NF-kappa-B essential modulator
Molecule details ›
Chains: B, D
Length: 70 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: NF-kappa-B essential modulator NEMO
Structure domains: L1 transposable element, trimerization domain
Length: 70 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9Y6K9 (Residues: 44-111; Coverage: 16%)
Sequence domains: NF-kappa-B essential modulator NEMO
Structure domains: L1 transposable element, trimerization domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X25
Spacegroup:
P212121
Expression systems:
- Not provided
- Escherichia coli BL21(DE3)
