X-ray diffraction
2.2Å resolution

Structure of a Poxvirus ifngbp/ifng Complex


Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero octamer
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon gamma Chain: L
Molecule details ›
Chain: L
Length: 139 amino acids
Theoretical weight: 16.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P01579 (Residues: 24-161; Coverage: 97%)
Gene name: IFNG
Structure domains: Growth Hormone; Chain: A;
IFNGR1 domain-containing protein Chain: R
Molecule details ›
Chain: R
Length: 250 amino acids
Theoretical weight: 28.72 KDa
Source organism: Ectromelia virus
Expression system: Drosophila melanogaster
  • Canonical: Q66793 (Residues: 17-266; Coverage: 94%)
Gene names: C4R, EVH185, IFNGR
Sequence domains: Interferon gamma receptor (IFNGR1)
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I222
Unit cell:
a: 92.63Å b: 119.13Å c: 184.74Å
α: 90° β: 90° γ: 90°
R R work R free
0.219 0.219 0.245
Expression systems:
  • Escherichia coli
  • Drosophila melanogaster