PDBe 3bb2

X-ray diffraction
1.5Å resolution

Crystal structure of L26D/D28N mutant of Human acidic fibroblast growth factor

Released:
Source organism: Homo sapiens
Primary publication:
A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J. Mol. Biol. 377 1251-64 (2008)
PMID: 18308335

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2221
Unit cell:
a: 75.442Å b: 96.7Å c: 108.071Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.228
Expression system: Escherichia coli BL21(DE3)