› 3b6w

X-ray diffraction
1.7Å resolution

Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution

Released:
DOI: 10.2210/pdb3b6w/pdb
PDB entry 3b6w coloured by chain, front view.
PDB entry 3b6w coloured by chain, side view.
PDB entry 3b6w coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.
Zhang W, Cho Y, Lolis E, Howe JR
J Neurosci 28 932-43 (2008)
PMID: 18216201

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 263 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand GLU 2 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 47.817Å b: 95.84Å c: 122.886Å
α: 90° β: 93.43° γ: 90°
R-values:
R R work R free
0.227 0.225 0.26
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
11 more

1 mention without citation

Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.
Zhang et al. (2008)