3ade

X-ray diffraction
2.8Å resolution

Crystal Structure of Keap1 in Complex with Sequestosome-1/p62

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Z2X8 (Residues: 309-624; Coverage: 51%)
Gene names: Inrf2, Keap1, Kiaa0132
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller
Sequestosome-1 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.53 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q64337 (Residues: 346-359; Coverage: 3%)
Gene names: A170, STAP, Sqstm1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P61
Unit cell:
a: 102.962Å b: 102.962Å c: 55.746Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.178 0.232
Expression systems:
  • Escherichia coli
  • Not provided