PDBe 2zz0

X-ray diffraction
2.8Å resolution

Crystal structure of human thioredoxin reductase I (SeCys 498 Cys)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase 1, cytoplasmic Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 513 amino acids
Theoretical weight: 56.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: GRIM12, KDRF, TXNRD1

Ligands and Environments


Cofactor: Ligand FAD 4 x FAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: C2221
Unit cell:
a: 121.086Å b: 135.414Å c: 345.795Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.277
Expression system: Escherichia coli