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Snapshot of a Michaelis complex in a sulfuryl transfer reaction: Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate.

Teramoto T, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y
Biochem Biophys Res Commun 383 83-7 (2009)
Related entries: 2zyt, 2zyu, 2zyw

Cited: 10 times
EuropePMC logo PMID: 19344693

Abstract

We report the crystal structure of mouse sulfotransferase, mSULT1D1, complexed with donor substrate 3'-phosphoadenosine 5'-phosphosulfate and accepter substrate p-nitrophenol. The structure is the first report of the native Michaelis complex of sulfotransferase. In the structure, three proposed catalytic residues (Lys48, Lys106, and His108) were in proper positions for engaging in the sulfuryl transfer reaction. The data strongly support that the sulfuryl transfer reaction proceeds through an S(N)2-like in-line displacement mechanism.

Reviews citing this publication (1)

  1. The PAPS-independent aryl sulfotransferase and the alternative disulfide bond formation system in pathogenic bacteria. Malojcić G, Glockshuber R. Antioxid Redox Signal 13 1247-1259 (2010)

Articles citing this publication (9)

  1. The gate that governs sulfotransferase selectivity. Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS. Biochemistry 52 415-424 (2013)
  2. Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction. Teramoto T, Fujikawa Y, Kawaguchi Y, Kurogi K, Soejima M, Adachi R, Nakanishi Y, Mishiro-Sato E, Liu MC, Sakakibara Y, Suiko M, Kimura M, Kakuta Y. Nat Commun 4 1572 (2013)
  3. Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes. Gulcan HO, Duffel MW. Arch Biochem Biophys 507 232-240 (2011)
  4. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL. ACS Chem Biol 7 1994-2003 (2012)
  5. Catalytic mechanism of Golgi-resident human tyrosylprotein sulfotransferase-2: a mass spectrometry approach. Danan LM, Yu Z, Ludden PJ, Jia W, Moore KL, Leary JA. J Am Soc Mass Spectrom 21 1633-1642 (2010)
  6. Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy. Taylor AB, Roberts KM, Cao X, Clark NE, Holloway SP, Donati E, Polcaro CM, Pica-Mattoccia L, Tarpley RS, McHardy SF, Cioli D, LoVerde PT, Fitzpatrick PF, Hart PJ. J Biol Chem 292 11154-11164 (2017)
  7. Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. Hirschmann F, Krause F, Baruch P, Chizhov I, Mueller JW, Manstein DJ, Papenbrock J, Fedorov R. Sci Rep 7 4160 (2017)
  8. Molecular cloning, expression, and functional analysis of a predicted sulfotransferase STF9 from Mycobacterium avium. Hossain MM, Moriizumi Y, Tanaka S, Kimura M, Kakuta Y. Mol Cell Biochem 350 155-162 (2011)
  9. On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases. Teramoto T, Adachi R, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y. FEBS Lett 583 3091-3094 (2009)


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