2zsd

X-ray diffraction
2.5Å resolution

Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with Coenzyme A

Released:
Source organism: Mycobacterium tuberculosis
Primary publication:
Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action.
Acta Crystallogr. D Biol. Crystallogr. 65 312-25 (2009)
PMID: 19307712

Function and Biology Details

Reaction catalysed:
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate kinase Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 35.7 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WPA7 (Residues: 1-312; Coverage: 100%)
Gene names: MTV017.45c, Rv1092c, coaA
Sequence domains: Phosphoribulokinase / Uridine kinase family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 103.84Å b: 103.84Å c: 89.604Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.206 0.24
Expression system: Escherichia coli BL21(DE3)