X-ray diffraction
2.5Å resolution

Crystal structure of AUH without RNA


Function and Biology Details

Reactions catalysed:
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O
Citramalyl-CoA = itaconyl-CoA + H(2)O
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Methylglutaconyl-CoA hydratase, mitochondrial Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 272 amino acids
Theoretical weight: 29.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q13825 (Residues: 68-339; Coverage: 80%)
Gene name: AUH
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 79.208Å b: 132.429Å c: 80.043Å
α: 90° β: 108.1° γ: 90°
R R work R free
0.197 0.197 0.263
Expression system: Escherichia coli BL21