› 2znd

X-ray diffraction
1.7Å resolution

Crystal structure of Ca2+-free form of des3-20ALG-2

Released:
DOI: 10.2210/pdb2znd/pdb
PDB entry 2znd coloured by chain, front view.
PDB entry 2znd coloured by chain, side view.
PDB entry 2znd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.
Suzuki H, Kawasaki M, Inuzuka T, Okumura M, Kakiuchi T, Shibata H, Wakatsuki S, Maki M
Structure 16 1562-73 (2008)
PMID: 18940611

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 6 Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 20.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75340 (Residues: 20-191; Coverage: 90%)
Gene names: ALG2, PDCD6
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand MRD 5 x MRD
Ligand PO4 2 x PO4
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P21212
Unit cell:
a: 71.148Å b: 48.833Å c: 54.183Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.222
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The ESCRT complexes.
Hurley JH. (2010)
8 more

3 mentions without citation

Structural basis of Sorcin-mediated calcium-dependent signal transduction.
Ilari et al. (2015)
2 more