› › Function and Biology

Crystal structure of the human Dmc1-M200V polymorphic variant

Source organism: Homo sapiens
Biochemical function: ATP-dependent DNA damage sensor activity
Biological process: double-strand break repair involved in meiotic recombination
Cellular component: site of double-strand break

Quick links

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08423
Domain description: Rad51
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
The deposited structure of PDB entry 2zjb contains 2 copies of Pfam domain PF08423 (Rad51) in Meiotic recombination protein DMC1/LIM15 homolog. Showing 1 copy in chain A.

PF14520
Domain description: Helix-hairpin-helix domain
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
The deposited structure of PDB entry 2zjb contains 2 copies of Pfam domain PF14520 (Helix-hairpin-helix domain) in Meiotic recombination protein DMC1/LIM15 homolog. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR020587
Domain description: DNA recombination and repair protein RecA, monomer-monomer interface
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR020588
Domain description: DNA recombination and repair protein RecA-like, ATP-binding domain
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR013632
Domain description: DNA recombination and repair protein Rad51-like, C-terminal
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR011940
Domain description: Meiotic recombination protein Dmc1
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR010995
Domain description: DNA repair Rad51/transcription factor NusA, alpha-helical
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
IPR016467
Domain description: DNA recombination and repair protein, RecA-like
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Meiotic recombination protein DMC1/LIM15 homolog
The deposited structure of PDB entry 2zjb contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Meiotic recombination protein DMC1/LIM15 homolog. Showing 1 copy in chain A.

Quick links