2zj4

X-ray diffraction
2.2Å resolution

Isomerase domain of human glucose:fructose-6-phosphate amidotransferase

Released:

Function and Biology Details

Reaction catalysed:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 42.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06210 (Residues: 332-699; Coverage: 53%)
Gene names: GFAT, GFPT, GFPT1
Sequence domains: SIS domain
Structure domains: Glucose-6-phosphate isomerase like protein; domain 1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: I4122
Unit cell:
a: 78.927Å b: 78.927Å c: 277.323Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.158 0.208
Expression system: Escherichia coli