Assemblies
Assembly Name:
alpha-thrombin complex and Hirudin variant-1
Multimeric state:
hetero trimer
Accessible surface area:
12528.83 Å2
Buried surface area:
3561.65 Å2
Dissociation area:
597
Å2
Dissociation energy (ΔGdiss):
0.82
kcal/mol
Dissociation entropy (TΔSdiss):
7.6
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-133065
Macromolecules
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Thrombin light chain
InterPro:
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00734 (Residues: 328-363; Coverage: 6%)
Pfam: Thrombin light chain
InterPro:
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Trypsin
InterPro:
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Pfam: Trypsin
InterPro:
- Serine proteases, trypsin domain
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin family, histidine active site
- Prothrombin/thrombin
- Serine proteases, trypsin family, serine active site
Chain: I
Length: 11 amino acids
Theoretical weight: 1.42 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.42 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
- Canonical: P01050 (Residues: 54-64; Coverage: 17%)
