PDBe 2zgh

X-ray diffraction
2.17Å resolution

Crystal Structure of active granzyme M bound to its product


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Granzyme M Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P51124 (Residues: 26-257; Coverage: 99%)
Gene names: GZMM, MET1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 688 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 74.598Å b: 74.598Å c: 112.87Å
α: 90° β: 90° γ: 120°
R R work R free
0.214 0.212 0.25
Expression systems:
  • Escherichia coli
  • Not provided