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Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus

Source organism: Staphylococcus aureus
Biochemical function: 15-cis-phytoene synthase activity
Biological process: carotenoid biosynthetic process
Cellular component: not assigned

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EC 2.5.1.96: 4,4'-diapophytoene synthase

Reaction catalysed:
(1a) 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate
Systematic name:
Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming)
Alternative Name(s):
  • C(30) carotene synthase
  • CrtM
  • DAP synthase
  • Dehydrosqualene synthase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00494
Domain description: Squalene/phytoene synthase
Occurring in:
  1. 4,4'-diapophytoene synthase
The deposited structure of PDB entry 2zco contains 1 copy of Pfam domain PF00494 (Squalene/phytoene synthase) in 4,4'-diapophytoene synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002060
Domain description: Squalene/phytoene synthase
Occurring in:
  1. 4,4'-diapophytoene synthase
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. 4,4'-diapophytoene synthase
IPR019845
Domain description: Squalene/phytoene synthase, conserved site
Occurring in:
  1. 4,4'-diapophytoene synthase
IPR033904
Domain description: Trans-isoprenyl diphosphate synthases, head-to-head
Occurring in:
  1. 4,4'-diapophytoene synthase
IPR044843
Domain description: Trans-isoprenyl diphosphate synthases, bacterial-type
Occurring in:
  1. 4,4'-diapophytoene synthase

Structure domain

CATH CATH domain
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. 4,4'-diapophytoene synthase
The deposited structure of PDB entry 2zco contains 1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in 4,4'-diapophytoene synthase. Showing 1 copy in chain A.

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