X-ray diffraction
1.63Å resolution

Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADP and 15-keto-PGE2


Function and Biology Details

Reaction catalysed:
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin reductase 2 Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 38.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8N8N7 (Residues: 1-351; Coverage: 100%)
Gene names: PTGR2, ZADH1
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand NAP 1 x NAP
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 39.815Å b: 68.019Å c: 122.884Å
α: 90° β: 90° γ: 90°
R R work R free
0.186 0.184 0.244
Expression system: Escherichia coli