› 2z4q

X-ray diffraction
2.3Å resolution

Crystal structure of a murine antibody FAB 528

Released:
DOI: 10.2210/pdb2z4q/pdb
PDB entry 2z4q coloured by chain, front view.
PDB entry 2z4q coloured by chain, side view.
PDB entry 2z4q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528.
Makabe K, Nakanishi T, Tsumoto K, Tanaka Y, Kondo H, Umetsu M, Sone Y, Asano R, Kumagai I
J Biol Chem 283 1156-66 (2008)
PMID: 17947238

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234842 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
anti egfr antibody fab, light chain Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.27 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
anti egfr antibody fab, heavy chain Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 23.61 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CD 2 x CD
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P62
Unit cell:
a: 126.6Å b: 126.6Å c: 68.278Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.191 0.228

Quick links

Citations

9 review citations

Development of therapeutic antibodies for the treatment of diseases.
Lu et al. (2020)
8 more

3 mentions without citation

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Krishnamurthy et al. (2012)
2 more