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Crystal structure of AR LBD with SHP peptide NR Box 2

X-ray diffraction
2.6Å resolution
PDB entry 2z4j coloured by chain, front view.
PDB entry 2z4j coloured by chain, side view.
PDB entry 2z4j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nuclear receptor subfamily 0 group B member 2 and Androgen receptor
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Multimeric state: hetero dimer
Accessible surface area: 11951.67 Å2
Buried surface area: 1578.68 Å2
Dissociation area: 458.62 Å2
Dissociation energy (ΔGdiss): 4.91 kcal/mol
Dissociation entropy (TΔSdiss): 7.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145244

Macromolecules

Androgen receptor
Chain: A
Length: 248 amino acids
Theoretical weight: 28.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 672-919; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Androgen receptor in PDB entry 2z4j, assembly 1, front view.
Androgen receptor in PDB entry 2z4j, assembly 1, side view.
Androgen receptor in PDB entry 2z4j, assembly 1, top view.
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Nuclear receptor subfamily 0 group B member 2
Chain: B
Length: 10 amino acids
Theoretical weight: 1.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15466 (Residues: 115-124; Coverage: 4%)
Gene names: NR0B2, SHP
Nuclear receptor subfamily 0 group B member 2 in PDB entry 2z4j, assembly 1, front view.
Nuclear receptor subfamily 0 group B member 2 in PDB entry 2z4j, assembly 1, side view.
Nuclear receptor subfamily 0 group B member 2 in PDB entry 2z4j, assembly 1, top view.
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