X-ray diffraction
2.7Å resolution

Crystal Structure of D-Dimer from Human Fibrin Complexed with Gly-His-Arg-Pro-Tyr-amide

Source organisms:
Entry authors: Doolittle RF, Pandi L

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero decamer (preferred)
hetero pentamer
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Fibrinogen alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 87 amino acids
Theoretical weight: 10.24 KDa
Source organism: Homo sapiens
  • Canonical: P02671 (Residues: 130-216; Coverage: 10%)
Gene name: FGA
Sequence domains: Fibrinogen alpha/beta chain family
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Fibrinogen beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 326 amino acids
Theoretical weight: 37.44 KDa
Source organism: Homo sapiens
  • Canonical: P02675 (Residues: 164-489; Coverage: 71%)
Gene name: FGB
Sequence domains:
Structure domains:
Fibrinogen gamma chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 324 amino acids
Theoretical weight: 36.69 KDa
Source organism: Homo sapiens
  • Canonical: P02679 (Residues: 114-433; Coverage: 75%)
  • Best match: P02679-2 (Residues: 114-437)
Gene names: FGG, PRO2061
Sequence domains:
Structure domains:
Fibrin B knob (tetrapeptide) Chains: S, T
Molecule details ›
Chains: S, T
Length: 4 amino acids
Theoretical weight: 468 Da
Fibrinogen beta chain Chains: I, J
Molecule details ›
Chains: I, J
Length: 5 amino acids
Theoretical weight: 631 Da
Source organism: Bos taurus
Expression system: Not provided
  • Canonical: P02676 (Residues: 22-26; Coverage: 1%)
Gene name: FGB

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 54.63Å b: 148.69Å c: 232.68Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.216 0.275
Expression system: Not provided