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Crystal structure of Keap1 complexed with Prothymosin alpha

X-ray diffraction
2Å resolution
PDB 2z32 coloured by chain and viewed from the front.
PDB 2z32 coloured by chain and viewed from the side.
PDB 2z32 coloured by chain and viewed from the top.
Source organism: Mus musculus
Assembly composition:
Non-polymer only dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: Non-polymer only dimer
Accessible surface area: 12100 Å2
Buried surface area: 1800 Å2
Dissociation area: 450 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -60 kcal/mol
Symmetry number: 1

Macromolecules

Kelch-like ECH-associated protein 1
Chain: A
Length: 318 amino acids
Theoretical weight: 35.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Z2X8 (Residues: 308-624; Coverage: 51%)
Gene names: Inrf2, Keap1, Kiaa0132
Pfam: Kelch motif
InterPro:
CATH: Kelch-type beta propeller
SCOP: Kelch motif
PDB 2z32 contains 1 copy of Kelch-like ECH-associated protein 1 in assembly 1. This protein is highlighted and viewed from the front.
PDB 2z32 contains 1 copy of Kelch-like ECH-associated protein 1 in assembly 1. This protein is highlighted and viewed from the side.
PDB 2z32 contains 1 copy of Kelch-like ECH-associated protein 1 in assembly 1. This protein is highlighted and viewed from the top.
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Prothymosin alpha, N-terminally processed
Chain: B
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P26350 (Residues: 39-54; Coverage: 14%)
Gene name: Ptma
PDB 2z32 contains 1 copy of Prothymosin alpha, N-terminally processed in assembly 1. This protein is highlighted and viewed from the front.
PDB 2z32 contains 1 copy of Prothymosin alpha, N-terminally processed in assembly 1. This protein is highlighted and viewed from the side.
PDB 2z32 contains 1 copy of Prothymosin alpha, N-terminally processed in assembly 1. This protein is highlighted and viewed from the top.
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