Solution NMR

Solution structure of the first Phorbol esters/diacylglycerol binding domain of human Protein kinase C, delta

Source organism: Homo sapiens
Entry authors: Abe H, Miyamoto K, Tochio N, Saito K, Sasagawa A, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein kinase C delta type regulatory subunit Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 8.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q05655 (Residues: 149-218; Coverage: 10%)
Gene name: PRKCD
Sequence domains: Phorbol esters/diacylglycerol binding domain (C1 domain)
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: torsion angle dynamics
Chemical shifts: BMR11151  
Expression system: Not provided