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Structure of the SCL:E47 complex bound to DNA

X-ray diffraction
2.87Å resolution
PDB entry 2ypb coloured by chain, front view.
PDB entry 2ypb coloured by chain, side view.
PDB entry 2ypb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcription factor E2-alpha and T-cell acute lymphocytic leukemia protein 1 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 12936.28 Å2
Buried surface area: 5511.74 Å2
Dissociation area: 1,213.58 Å2
Dissociation energy (ΔGdiss): 18.31 kcal/mol
Dissociation entropy (TΔSdiss): 10.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115952

Macromolecules

T-cell acute lymphocytic leukemia protein 1
Chain: A
Length: 91 amino acids
Theoretical weight: 10.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17542 (Residues: 180-253; Coverage: 22%)
Gene names: BHLHA17, SCL, TAL1, TCL5
Pfam: Helix-loop-helix DNA-binding domain
InterPro:
CATH: Helix-loop-helix DNA-binding domain
T-cell acute lymphocytic leukemia protein 1 in PDB entry 2ypb, assembly 1, front view.
T-cell acute lymphocytic leukemia protein 1 in PDB entry 2ypb, assembly 1, side view.
T-cell acute lymphocytic leukemia protein 1 in PDB entry 2ypb, assembly 1, top view.
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Transcription factor E2-alpha
Chain: B
Length: 82 amino acids
Theoretical weight: 9.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15923 (Residues: 538-616; Coverage: 12%)
Gene names: BHLHB21, E2A, ITF1, TCF3
Pfam: Helix-loop-helix DNA-binding domain
InterPro:
CATH: Helix-loop-helix DNA-binding domain
Transcription factor E2-alpha in PDB entry 2ypb, assembly 1, front view.
Transcription factor E2-alpha in PDB entry 2ypb, assembly 1, side view.
Transcription factor E2-alpha in PDB entry 2ypb, assembly 1, top view.
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DNA chain E
Name: EBOX FORWARD
Representative chains: E
Length: 11 nucleotides
Theoretical weight: 3.28 KDa
EBOX FORWARD in PDB entry 2ypb, assembly 1, front view.
EBOX FORWARD in PDB entry 2ypb, assembly 1, side view.
EBOX FORWARD in PDB entry 2ypb, assembly 1, top view.
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DNA chain F
Name: EBOX REVERSE
Representative chains: F
Length: 11 nucleotides
Theoretical weight: 3.42 KDa
EBOX REVERSE in PDB entry 2ypb, assembly 1, front view.
EBOX REVERSE in PDB entry 2ypb, assembly 1, side view.
EBOX REVERSE in PDB entry 2ypb, assembly 1, top view.
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